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Article

Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element.

The Journal of biological chemistry - 2 Jul 2004

François Mathias, Richette Pascal, Tsagris Lydia, Raymondjean Michel, Fulchignoni-Lataud Marie-Claude, Forest Claude, Savouret Jean-François, Corvol Marie-Thérèse

Abstract excerpt

Interleukin-1beta (IL-1beta) induces degradation via hyperexpression of an array of genes, including metalloproteinases (MMP), in cartilage cells during articular degenerative diseases. In contrast, natural ligands for peroxisome proliferator-activated receptors (PPARs) display protective anti-cy...

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Source

Identifiers

PMID: 15090544
DOI: 10.1074/jbc.M312708200

Genes

MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15090544-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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