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Article

Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts.

The Journal of laboratory and clinical medicine - 1 Jul 2003

Khan Emma, Abu-Amer Yousef

Abstract excerpt

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells. Activation of this nuclear receptor inhibits gene expression in part by antagonizing the activities of several transcription factors. In this study we examined inhibitory mechanisms of osteoblast differentiation markers by activating PPAR-gamma. Our data...

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Identifiers

PMID: 12878983
DOI: 10.1016/S0022-2143(03)00058-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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