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Article

Inhibition of MMP-9 expression by PPAR activators in human bronchial epithelial cells

28 Aug 2003

Abstract excerpt

BACKGROUND: The release of matrix degrading enzymes such as matrix metalloproteinase 9 (MMP-9) from bronchial epithelial cells is critically involved in airway wall remodelling in chronic inflammatory processes of the respiratory system. MMP-9 expression is induced by inflammatory mediators such as tumour necrosis factor (TNF)-alpha, but to date nothing is known about the mechanisms of inhibition of MMP-9...

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PMID: 12947137
DOI: 10.1136/thorax.58.9.778

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