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Article

The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function.

Kidney international - 1 Apr 2004

Li Jian, Codina Juan, Petroske Elizabeth, Werle Mike J, DuBose Thomas D

Abstract excerpt

BACKGROUND: The present experiments were designed to study the importance of the carboxy-terminus of colonic H(+), K(+)-ATPase alpha-subunit (HKalpha(2)), for both function as well as integrity of assembly with beta1-Na(+), K(+)-ATPase. METHODS: For this purpose, a mutation of 84 amino acids in the carboxy-terminus was created (DeltaHKalpha(2)) and HEK-293 cells were used as expression systems for functional...

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Identifiers

PMID: 15086469
DOI: 10.1111/j.1523-1755.2004.00507.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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