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Article

Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Combarros Onofre, Infante Jon, Llorca Javier, Berciano José

Abstract excerpt

Memory acquisition and consolidation are associated with an increase in brain-derived neurotrophic factor (BDNF) in synapses, particularly those innervating the hippocampus and cerebral cortex. A polymorphism producing an amino acid substitution (valine to methionine) at codon 66 of the BDNF gene...

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Source

Identifiers

PMID: 15084795
DOI: 10.1159/000077736

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15084795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease.PMID 15084795Read ↗

Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset.Semantic proximity Read ↗

Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.Semantic proximity Read ↗

Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population.Semantic proximity Read ↗

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan.Semantic proximity Read ↗

Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease.Semantic proximity Read ↗

Val66Met Polymorphism in BDNF Has No Sexual and APOE ε4 Status-Based Dimorphic Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

BDNF genetic variations increase the risk of Alzheimer's disease-related depression.Semantic proximity Read ↗

Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North Indian population.Semantic proximity Read ↗

BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.Semantic proximity Read ↗

BDNF Val66Met moderates increases in CSF t-tau and p-tau181 in early sporadic Alzheimer’s disease: A prospective cohort studySemantic proximity Read ↗

BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response.Semantic proximity Read ↗

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