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Article

Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Combarros Onofre, Infante Jon, Llorca Javier, Berciano José

Abstract excerpt

Memory acquisition and consolidation are associated with an increase in brain-derived neurotrophic factor (BDNF) in synapses, particularly those innervating the hippocampus and cerebral cortex. A polymorphism producing an amino acid substitution (valine to methionine) at codon 66 of the BDNF gene could affect intracellular processing and secretion of BDNF and lead to impairments in hippocampal function....

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Identifiers

PMID: 15084795
DOI: 10.1159/000077736

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease.PMID 15084795Read ↗

Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset.Semantic proximity Read ↗

Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.Semantic proximity Read ↗

Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population.Semantic proximity Read ↗

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan.Semantic proximity Read ↗

Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease.Semantic proximity Read ↗

Val66Met Polymorphism in BDNF Has No Sexual and APOE ε4 Status-Based Dimorphic Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

BDNF genetic variations increase the risk of Alzheimer's disease-related depression.Semantic proximity Read ↗

Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North Indian population.Semantic proximity Read ↗

BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.Semantic proximity Read ↗

BDNF Val66Met moderates increases in CSF t-tau and p-tau181 in early sporadic Alzheimer’s disease: A prospective cohort studySemantic proximity Read ↗

BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response.Semantic proximity Read ↗

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