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Article

The telomere theory of reproductive senescence in women

26 May 2006

Abstract excerpt

PURPOSE OF REVIEW: A unifying theory of reproductive aging, based on telomere shortening, is proposed. RECENT FINDINGS: Telomere shortening may mediate both 'hits' involved in reproductive aging, that is late exit from the fetal production line and long interval to ovulation in the adult. SUMMARY: As women age egg dysfunction increases, with meiotic nondisjunction, embryonic arrest, apoptosis, and miscarriage....

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Share to Birth, Development, and Health
Share to Genetics, Aging, and Longevity in Model Organisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16735827
DOI: 10.1097/01.gco.0000193019.05686.49

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