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Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin

25 Feb 2004

Abstract excerpt

INTRODUCTION: In order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential. METHODS: Through suppression subtractive hybridization coupled to the microarray, we found osteopontin (OPN) to be a highly expressed gene in the tumors of the...

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PMID: 15084239
DOI: 10.1186/bcr768

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