Article
The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene.
Genomics - 1 May 2004
Jahoda Colin A B, Kljuic Ana, O'Shaughnessy Ryan, Crossley Neil, Whitehouse C Jenna, Robinson Mark, Reynolds Amanda J, Demarchez Michel, Porter Rebecca M, Shapiro Lawrence, Christiano Angela M
Abstract excerpt
Desmosomal cadherins are essential cell adhesion molecules present throughout the epidermis and other organs, whose major function is to provide mechanical integrity and stability to epithelial cells in a wide variety of tissues. We recently identified a novel desmoglein family member, Desmoglein 4 (Dsg4), using a positional cloning approach in two families with localized autosomal recessive hypotrichosis (LAH)...
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