Article
Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation.
Molecular biology of the cell - 1 Jun 2004
Grimme Stephen J, Gao Xiang-Dong, Martin Paul S, Tu Kim, Tcheperegine Serguei E, Corrado Kathleen, Farewell Anne E, Orlean Peter, Bi Erfei
Abstract excerpt
The essential GAB1 gene, which encodes an endoplasmic reticulum (ER)-membrane protein, was identified in a screen for mutants defective in cellular morphogenesis. A temperature-sensitive gab1 mutant accumulates complete glycosylphosphatidylinositol (GPI) precursors, and its temperature sensitivity is suppressed differentially by overexpression of different subunits of the GPI transamidase, from strong suppression...
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