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Article

Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor.

Cancer science - 1 Dec 2012

Tomosugi Mitsuhiro, Sowa Yoshihiro, Yasuda Shusuke, Tanaka Ryoichi, te Riele Hein, Ikawa Haruna, Koyama Makoto, Sakai Toshiyuki

Abstract excerpt

In most human malignant tumors, retinoblastoma tumor-suppressor gene (RB) product is inactivated by phosphorylation. Therefore, cancer preventive agents or molecular-targeting agents can inhibit the tumor growth at G(1) phase through RB reactivation. However, little is known about the effectiveness of RB reactivating agents against malignancies with mutated RB. We report here that chemopreventive agent flavone,...

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Identifiers

PMID: 22957647
DOI: 10.1111/cas.12012
PMCID: PMC7659262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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