Telomeres, telomerase and senescence.

doi:10.1002/bies.950120803

Back to search

Article

Telomeres, telomerase and senescence.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 1990

Greider C W

Abstract excerpt

Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an un...

Topics

Animals
Base Sequence
Chromosomes
DNA Nucleotidylexotransferase
DNA Replication
DNA-Directed DNA Polymerase
Models, Genetic
Molecular Sequence Data
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.