Article
GADD45β, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens.
Oncotarget - 18 Oct 2016
Zhang Xinheng, Yan Zhuanqiang, Li Xinjian, Lin Wencheng, Dai Zhenkai, Yan Yiming, Lu Piaopiao, Chen Weiguo, Zhang Huanmin, Chen Feng, Ma Jingyun, Xie Qingmei
Abstract excerpt
Avian leukosis virus subgroup J (ALV-J) is a retroviruses that induces neoplasia, hepatomegaly, immunosuppression and poor performance in chickens. The tumorigenic and pathogenic mechanisms of ALV-J remain a hot topic. To explore anti-tumor genes that promote resistance to ALV-J infection in chickens, we bred ALV-J resistant and susceptible chickens (F3 generation). RNA-sequencing (RNA-Seq) of liver tissue from...
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