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Article

High expression of both mutant and wild-type alleles of c-kit in gastrointestinal stromal tumors.

Biochimica et biophysica acta - 5 Apr 2004

Théou Nathalie, Tabone Séverine, Saffroy Raphael, Le Cesne Axel, Julié Catherine, Cortez Annie, Lavergne-Slove Anne, Debuire Brigitte, Lemoine Antoinette, Emile Jean-François

Abstract excerpt

Most gastrointestinal stromal tumors (GISTs) contain activating mutations of the proto-oncogene c-kit. The GNNK- isoform of c-kit has a greater oncogenic potential than the GNNK+ isoform. We studied tumors from 29 patients with GIST, 19 of whom had c-kit mutations, and compared them to normal cel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

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Share to Proto-Oncogene Proteins c-kit

Share to Stomach Neoplasms

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Source

Identifiers

PMID: 15062876
DOI: 10.1016/j.bbadis.2003.12.011

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15062876-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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