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Article

LIM-kinase as a regulator of actin dynamics in spermatogenesis.

Cytogenetic and genome research - 1 Jan 2003

Takahashi H, Funakoshi H, Nakamura T

Abstract excerpt

We have identified LIM-kinase (LIMK1 and LIMK2), the only known catalytic protein among LIM-family molecules. Both LIMK1 and LIMK2 phosphorylate (inactivate) cofilin, an actin depolymerizing factor, and induce actin cytoskeleton reorganization. We as well as others concurrently demonstrated that LIMK activation was regulated by the Rho family of GTPases, and LIMK1 and LIMK2 share the distinct functional portion...

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Topics

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15051950
DOI: 10.1159/000076815

Genes

LIMK1
LIMK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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LIM-kinase as a regulator of actin dynamics in spermatogenesis.PMID 15051950Read ↗

The Role of LIM Kinase in the Male Urogenital SystemSemantic proximity Read ↗

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LIM kinases: cofilin and beyondSemantic proximity Read ↗

LIM Kinase 2 Is Widely Expressed in All TissuesSemantic proximity Read ↗

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p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.Semantic proximity Read ↗

Sertoli-Germ Cell Adherens Junction Dynamics in the Testis Are Regulated by RhoB GTPase via the ROCK/LIMK Signaling Pathway1Semantic proximity Read ↗

Role of Src family kinases and N-Myc in spermatogonial stem cell proliferationSemantic proximity Read ↗

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.Semantic proximity Read ↗

Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2.Semantic proximity Read ↗

Keratinocyte migration in the developing eyelid requires LIMK2.Semantic proximity Read ↗

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