Article
Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2004
Yang Shilin, Yang Yi, Raycraft John, Zhang Hongtao, Kanan Sandra, Guo Yajun, Ronai Ze'ev, Hellstrom Ingegerd, Hellstrom Karl Erik
Abstract excerpt
Interactions between CD83 and its ligand(s) can up-regulate immune responses. M2-CD83 cells, derived by transfecting the M2 clone of mouse melanoma K1735 cells to express mouse CD83, were rejected by syngeneic mice, unless they were injected with a CD83Ig fusion protein. Rejection was mediated by CD4+ and CD8+ T cells plus natural killer cells, whereas rejection of M2-1D8 cells, which express anti-CD137...
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