Article
SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects.
Human genetics - 1 Jul 2005
Deak Kristen L, Boyles Abee L, Etchevers Heather C, Melvin Elizabeth C, Siegel Deborah G, Graham Felicia L, Slifer Susan H, Enterline David S, George Timothy M, Vekemans Michel, McClay David, Bassuk Alexander G, Kessler John A, Linney Elwood, Gilbert John R, Speer Marcy C
Abstract excerpt
Neural tube defects (NTDs) are common birth defects, occurring in approximately 1/1,000 births; both genetic and environmental factors are implicated. To date, no major genetic risk factors have been identified. Throughout development, cell adhesion molecules are strongly implicated in cell-cell interactions, and may play a role in the formation and closure of the neural tube. To evaluate the role of neural cell...
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