Article
Genotype relationships in the CYP3A locus in Caucasians.
Cancer letters - 15 Apr 2004
Dally Heike, Bartsch Helmut, Jäger Birgit, Edler Lutz, Schmezer Peter, Spiegelhalder Bertold, Dienemann Hendrik, Drings Peter, Kayser Klaus, Schulz Volker, Risch Angela
Abstract excerpt
Genetic polymorphisms of the human CYP3A family affect clinical drug efficacy and may modify cancer risk. CYP3A genes show high sequence similarity that had previously lead to misallocation of CYP3A polymorphisms. Recent studies indicated a high degree of or even complete linkage for certain CYP3A alleles. Reliable LightCycler-based genotyping methods were developed and their degree of linkage in a large...
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