The mutator pathway is a feature of immunodeficiency-related lymphomas.

doi:10.1073/pnas.0400945101

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Article

The mutator pathway is a feature of immunodeficiency-related lymphomas.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2004

Duval Alex, Raphael Martine, Brennetot Caroline, Poirel Helene, Buhard Olivier, Aubry Alban, Martin Antoine, Krimi Amor, Leblond Veronique, Gabarre Jean, Davi Frederic, Charlotte Frederic, Berger Francoise, Gaidano Gianluca, Capello Daniela, Canioni Danielle, Bordessoule Dominique, Feuillard Jean, Gaulard Philippe, Delfau Marie Helene, Ferlicot Sophie, Eclache Virginie, Prevot Sophie, Guettier Catherine, Lefevre Pascale Cornillet, Adotti Francoise, Hamelin Richard

Abstract excerpt

The mutator phenotype caused by defects in the mismatch repair system is observed in a subset of solid neoplasms characterized by widespread microsatellite instability-high (MSI-H). It is known to be very rare in non-Hodgkin lymphomas (NHL), whereas mutator NHL is the most frequent tumor subtype in mismatch repair-deficient mice. By screening a series of 603 human NHL with specific markers of the mutator...

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PMID: 15047891
DOI: 10.1073/pnas.0400945101
PMCID: PMC387363

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