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Article

Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model

6 Aug 2012

Abstract excerpt

In the field of bone regeneration, BMP-2 is considered one of the most important growth factors because of its strong osteogenic activity, and is therefore extensively used in clinical practice. However, the short half-life of BMP-2 protein necessitates the use of supraphysiological doses, leading to severe side-effects. This study investigated the efficiency of bone formation at ectopic and orthotopic sites as a...

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PMID: 22888035
DOI: 10.1002/term.1571

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