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Article

C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase.

The Journal of biological chemistry - 4 Jun 2004

Schlattner Uwe, Gehring Florian, Vernoux Nathalie, Tokarska-Schlattner Malgorzata, Neumann Dietbert, Marcillat Olivier, Vial Christian, Wallimann Theo

Abstract excerpt

High affinity interaction between octameric mitochondrial creatine kinase (MtCK) and the phospholipid cardiolipin in the inner mitochondrial membrane plays an important role in metabolite channeling between MtCK and inner membrane adenylate translocator, which itself is tightly bound to cardiolipin. Three C-terminal basic residues revealed as putative cardiolipin anchors in the x-ray structures of MtCK and...

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PMID: 15044463
DOI: 10.1074/jbc.M314158200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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