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Article

Structural asymmetry and intersubunit communication in muscle creatine kinase.

Acta crystallographica. Section D, Biological crystallography - 1 Mar 2007

Ohren Jeffrey F, Kundracik Melisa L, Borders Charles L, Edmiston Paul, Viola Ronald E

Abstract excerpt

The structure of a transition-state analog complex of a highly soluble mutant (R134K) of rabbit muscle creatine kinase (rmCK) has been determined to 1.65 A resolution in order to elucidate the structural changes that are required to support and regulate catalysis. Significant structural asymmetry is seen within the functional homodimer of rmCK, with one monomer found in a closed conformation with the active site...

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Identifiers

PMID: 17327675
DOI: 10.1107/S0907444906056204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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