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Article

Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Feb 2004

Wyszynski D F, Baldwin C T, Cleves M A, Amirault Y, Nolan V G, Farrell J J, Bisbee A, Kutlar A, Farrer L A, Steinberg M H

Abstract excerpt

In patients with sickle cell anemia, fetal hemoglobin (HbF) concentrations vary by 2 orders of magnitude. This variance may be a result of heterogeneity in gene regulatory elements; accordingly, we searched for single nucleotide polymorphisms (SNPs) that might identify this variation. More than 180 SNPs were studied in 38 genes in 280 sickle cell anemia patients. The strongest association with HbF was found with...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 6

Share to Fetal Hemoglobin

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Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 15040424

Genes

MAP7
PEX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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