The age incidence of childhood acute lymphoblastic leukaemia.

doi:10.1016/0306-9877(91)90075-a

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Article

The age incidence of childhood acute lymphoblastic leukaemia.

Medical hypotheses - 1 May 1991

Morris J A

Abstract excerpt

A mathematical model of childhood acute lymphoblastic leukaemia (ALL) is presented which is based on the assumptions that: 1) malignant clones of lymphoblasts arise by spontaneous mutation; 2) this is normally prevented by repair systems which either cause intracellular DNA repair or eliminate the malignant clone; and 3) the repair systems are fallible and their performance decays at random with time. If the...

Topics

Adolescent
Age Factors
Child
Child, Preschool
DNA Repair
Humans
Infant
Models, Biological
Mutation
Neoplastic Stem Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Socioeconomic Factors

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