Article
Ionizing radiation and genetic risks. VII. The concept of mutation component and its use in risk estimation for Mendelian diseases.
Mutation research - 25 May 1998
Chakraborty R, Yasuda N, Denniston C, Sankaranarayanan K
Abstract excerpt
The responsiveness of Mendelian diseases to an increase in the mutation rate is studied by using the concept of the mutation component (MC) of genetic diseases. Algebraic expressions to evaluate MC at any specific generation following either a one-time or a permanent increase in mutation rate are...
Topics
- Animals
- Dose-Response Relationship, Radiation
- Genetic Diseases, Inborn
- Humans
- Models, Genetic
- Models, Statistical
- Mutation
- Radiation, Ionizing
- Risk Assessment