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Ionizing radiation and genetic risks. VII. The concept of mutation component and its use in risk estimation for Mendelian diseases.

Mutation research - 25 May 1998

Chakraborty R, Yasuda N, Denniston C, Sankaranarayanan K

Abstract excerpt

The responsiveness of Mendelian diseases to an increase in the mutation rate is studied by using the concept of the mutation component (MC) of genetic diseases. Algebraic expressions to evaluate MC at any specific generation following either a one-time or a permanent increase in mutation rate are derived and are illustrated with numerical examples. For a one-time increase in mutation rate, the analysis shows that...

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PMID: 9685709
DOI: 10.1016/s0027-5107(98)00020-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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