Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress.

Alcoholism, clinical and experimental research - 1 May 2003

Barr Christina S, Newman Timothy K, Becker Michelle L, Champoux Maribeth, Lesch Klaus Peter, Suomi Stephen J, Goldman David, Higley J Dee

Abstract excerpt

BACKGROUND: Decreased sensitivity to alcohol has been demonstrated to be a predictor of alcoholism in humans, and variation in the gene-linked polymorphic region of the serotonin transporter (5-HTTLPR) is associated with the response to the motor-impairing effects of alcohol. In a nonhuman primate model of excessive alcohol intake, we have shown that decreased serotonin turnover is associated with both lower...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholic Intoxication
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Macaca mulatta

Share to Membrane Glycoproteins

Share to Membrane Transport Proteins

Share to Serotonin Plasma Membrane Transport Proteins

Share to Stress, Physiological

Source

Identifiers

PMID: 12766626
DOI: 10.1097/01.ALC.0000067976.62827.ED

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress.PMID 12766626Read ↗

Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.Semantic proximity Read ↗

Moderate prenatal alcohol exposure and serotonin genotype interact to alter CNS serotonin function in rhesus monkey offspring.Semantic proximity Read ↗

Early experience and serotonin transporter gene variation interact to influence primate CNS function.Semantic proximity Read ↗

Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques.Semantic proximity Read ↗

Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaques.Semantic proximity Read ↗

Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants.Semantic proximity Read ↗

Non-human primate models of alcohol-related phenotypes: the influence of genetic and environmental factors.Semantic proximity Read ↗

An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk.Semantic proximity Read ↗

Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences.Semantic proximity Read ↗

Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques.Semantic proximity Read ↗

Effects of early experience and genotype on serotonin transporter regulation in infant rhesus macaques.Semantic proximity Read ↗

A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.