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Article

Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats.

Biological psychiatry - 1 Apr 2004

Salomé Nicolas, Salchner Peter, Viltart Odile, Sequeira Henrique, Wigger Alexandra, Landgraf Rainer, Singewald Nicolas

Abstract excerpt

BACKGROUND: Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety. METHODS: We used Fos expression for mapping of neuronal activation patterns in response to mild anxiety-provoking challenges. RESULTS: In both lines, exposure to an open field (OF) or the open arm (OA) of an elevated plus-maze induced Fos...

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PMID: 15039000
DOI: 10.1016/j.biopsych.2003.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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