Article
Mitochondrial respiratory chain disorders I: mitochondrial DNA defects.
Lancet (London, England) - 22 Jan 2000
Leonard J V, Schapira A H
Abstract excerpt
Mitochondria have a pivotal role in cell metabolism, being the major site of ATP production via oxidative phosphorylation (OXPHOS); they have a critical role in apoptotic cell death; and they also contribute to human genetics since mitochondria have a functional genome separate from that of nuclear DNA. Defects of mitochondrial metabolism are associated with a wide spectrum of disease. An Important part of this...
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