Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.

Journal of structural biology - 1 Jan 2000

Indig Fred Eliezer, Partridge Juneth Joaquin, von Kobbe Cayetano, Aladjem Mirit I, Latterich Martin, Bohr Vilhelm A

Abstract excerpt

We have previously shown that the Werner syndrome helicase, WRNp, a member of the RecQ helicase family, forms a tight molecular complex with the p97/Valosin containing protein (VCP), a member of the AAA (ATPases associated with diverse cellular activities) family of proteins. This interaction is disrupted by chemical agents that confer DNA damage, suggesting that VCP plays an important role in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Exodeoxyribonucleases

Share to Macromolecular Substances

Share to RecQ Helicases

Share to Valosin Containing Protein

Share to Werner Syndrome Helicase

Source

Identifiers

PMID: 15037256
DOI: 10.1016/j.jsb.2003.11.009

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.PMID 15037256Read ↗

DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP.Semantic proximity Read ↗

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesisSemantic proximity Read ↗

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.Semantic proximity Read ↗

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.Semantic proximity Read ↗

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrestSemantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome proteinSemantic proximity Read ↗

Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.Semantic proximity Read ↗

D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.Semantic proximity Read ↗

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.Semantic proximity Read ↗

VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration.Semantic proximity Read ↗

Structure and function of the AAA+ ATPase p97/Cdc48p.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.