The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility.

doi:10.1128/AAC.36.4.826

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Article

The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility.

Antimicrobial agents and chemotherapy - 1 Apr 1992

Vuorio R, Vaara M

Abstract excerpt

The conditionally lethal lpxA2 mutant of Escherichia coli, which lacks detectable UDP-N-acetylglucosamine acyltransferase activity and which produces greatly reduced amounts of lipid A after a shift to 42 degrees C (S. Galloway and C. R. H. Raetz, J. Biol. Chem. 265:6394-6402, 1990), was found to...

Topics

Drug Resistance, Microbial
Escherichia coli
Lipid A
Microbial Sensitivity Tests
Mutation
Osmolar Concentration

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