Article
Assessment of in vivo chemotherapy-induced DNA damage in a p53-mutated rat tumor by micronuclei assay.
Annals of the New York Academy of Sciences - 1 Dec 2003
Driessens Gregory, Harsan Laura, Browaeys Patrick, Giannakopoulos Xenofon, Velu Thierry, Bruyns Catherine
Abstract excerpt
Production of DNA damage is the basis of cancer treatments such as chemo- and radiotherapy. Such treatments induce mitotic catastrophe, a form of cell death resulting from abnormal mitosis and leading to the formation of interphase cells with multiple micronuclei. In this study, we compared apoptosis induction and micronuclei formation to assess the DNA damage provoked in vivo by cytotoxic agents in established...
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