Article
Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation.
The Journal of biological chemistry - 6 Feb 2004
Bian Xin, Giordano Thomas D, Lin Huey-Jen, Solomon Gabriel, Castle Valerie P, Opipari Anthony W
Abstract excerpt
Stromal or S-type tumor cells are a distinct lineage found in neuroblastoma tumors and have an important role in the biology of this disease. Anticancer agents induce apoptosis through death receptor- and mitochondria-initiated pathways. The object of this work was to determine the involvement of these pathways in the response to doxorubicin (Dox) and cisplatin (CDDP) in S-type neuroblastoma cells. Both drugs...
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