Article
TRAIL activates a caspase 9/7-dependent pathway in caspase 8/10-defective SK-N-SH neuroblastoma cells with two functional end points: induction of apoptosis and PGE2 release.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Zauli Giorgio, Milani Daniela, Rimondi Erika, Baldini Giovanna, Nicolin Vanessa, Grill Vittorio, Secchiero Paola
Abstract excerpt
Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of malignant cell types. In this study, we demonstrated that TRAIL induced a moderate but significant increase of apoptosis in the caspase 8/10-deficient SK-N-SH neuroblastoma cell line, through activation of a novel...
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