Article
Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose.
The Biochemical journal - 1 Jul 2004
Marin Silvia, Lee W-N Paul, Bassilian Sara, Lim Shu, Boros Laszlo G, Centelles Josep J, FernAndez-Novell Josep Maria, Guinovart Joan J, Cascante Marta
Abstract excerpt
Recent studies in metabolic profiling have underscored the importance of the concept of a metabolic network of pathways with special functional characteristics that differ from those of simple reaction sequences. The characterization of metabolic functions requires the simultaneous measurement of substrate fluxes of interconnecting pathways. Here we present a novel stable isotope method by which the forward and...
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