In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research.

Abstract excerpt

In the postgenomic era of biology, much attention has been given to functional genomics, or the relation between genes and higher levels of organization in the cell. The latter are typically represented as mRNA, protein, or organic metabolite complements. The theme of this review is that the operational unit of function in complex biological systems is more properly seen as the fully assembled metabolic pathway...

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