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Article

Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation.

Immunity - 1 Mar 2004

Dinarello Charles A

Abstract excerpt

Cytokine-mediated inflammation is a target for novel therapies as well as for fundamental research. A single amino acid mutation in the NALP-3 gene controlling the activation of caspase-1 results in increased processing of the inactive IL-1beta precursor and release of the active cytokine. Blocki...

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Identifiers

PMID: 15030767
DOI: 10.1016/s1074-7613(04)00055-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15030767-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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