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Article

Molecular pathology of ovarian carcinomas.

Virchows Archiv : an international journal of pathology - 1 Aug 1998

Matias-Guiu X, Prat J

Abstract excerpt

There is evidence that ovarian cancer may be derived from the progressive transformation of benign and/or borderline tumours. Mutations involving different oncogenes and tumour suppressor genes accumulate during the process of malignant transformation, and the alterations of genes involved in the pathogenesis of familial ovarian cancer are probably early events in ovarian tumorigenesis. BRCA-1 and BRCA-2 act as...

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PMID: 9737787
DOI: 10.1007/s004280050224

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