Article
Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases.
Genomics - 1 Apr 2004
Ng Maggie C Y, Wang Ying, So Wing-Yee, Cheng Suzanne, Visvikis Sophie, Zee Robert Y L, Fernandez-Cruz Arturo, Lindpaintner Klaus, Chan Juliana C N
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are commonly used to study genetics for common diseases and predict pharmacological response. The selection of likely informative SNPs in association studies depends on their allele frequencies and on the linkage disequilibrium (LD) between SNPs, both of which may show interethnic differences. Among three populations consisting of 207 Chinese, 858 French, and 395 Spanish, we...
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