Article
Sequence diversity in 36 candidate genes for cardiovascular disorders.
American journal of human genetics - 1 Jul 1999
Cambien F, Poirier O, Nicaud V, Herrmann S M, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets J B, Arveiler D, Luc G, Tiret L
Abstract excerpt
Two strategies involving whole-genome association studies have been proposed for the identification of genes involved in complex diseases. The first one seeks to characterize all common variants of human genes and to test their association with disease. The second one seeks to develop dense maps of single-nucleotide polymorphisms (SNPs) and to detect susceptibility genes through linkage disequilibrium. We...
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