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Article

Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.

Journal of cardiovascular electrophysiology - 1 Feb 2004

Kobori Atsushi, Sarai Nobuaki, Shimizu Wataru, Nakamura Yoshihide, Murakami Yosuke, Makiyama Takeru, Ohno Seiko, Takenaka Kotoe, Ninomiya Tomonori, Fujiwara Yuichiro, Matsuoka Satoshi, Takano Makoto, Noma Akinori, Kita Toru, Horie Minoru

Abstract excerpt

INTRODUCTION: Beta-blockers are widely used to prevent the lethal cardiac events associated with the long QT syndrome (LQTS), especially in KCNQ1-related LQTS (LQT1) patients. Some LQT1 patients, however, are refractory to this therapy. METHODS AND RESULTS: Eighteen symptomatic LQTS patients (12...

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Source

Identifiers

PMID: 15028050
DOI: 10.1046/j.1540-8167.2004.03212.x

Genes

KCNQ1
KCNH2
KCNJ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15028050-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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