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Article

The relationship between cisplatin - induced apoptosis and p53 , bcl - 2 and bax expression in human lung cancer cells

31 Jan 1999

Abstract excerpt

OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the molecular events of cisplatin-resistance in lung cancers. METHODS: Three parental human lung cancer cell lines (PC9, PC14 and H69) and their in vitro selected cisplatin-resistant sublines were examined. Cells treated with cisplatin were processed...

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PMID: 10063313
DOI: 10.3904/kjim.1999.14.1.42

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