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Article

Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion.

Cancer research - 15 Mar 2004

Sowa Hideaki, Kaji Hiroshi, Kitazawa Riko, Kitazawa Sohei, Tsukamoto Tatsuo, Yano Shozo, Tsukada Toshihiko, Canaff Lucie, Hendy Geoffrey N, Sugimoto Toshitsugu, Chihara Kazuo

Abstract excerpt

Primary hyperparathyroidism is a common endocrine disorder caused by parathyroid gland enlargement and excessive parathyroid hormone (PTH) secretion. However, the precise mechanisms of tumorigenesis of the parathyroids are unknown. Here we have investigated the roles of transforming growth factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15026366
DOI: 10.1158/0008-5472.can-03-3334

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15026366-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion.PMID 15026366Read ↗

The role of menin in parathyroid tumorigenesis.Semantic proximity Read ↗

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Tumor Suppressor Menin Regulates Expression of Insulin-Like Growth Factor Binding Protein 2Semantic proximity Read ↗

Transfection of the Multiple Endocrine Neoplasia Type 1 Gene to a Human Endocrine Pancreatic Tumor Cell Line Inhibits Cell Growth and Affects Expression of JunD, δ-Like Protein 1/Preadipocyte Factor-1, Proliferating Cell Nuclear Antigen, and QM/Jif-1Semantic proximity Read ↗

Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast LineageSemantic proximity Read ↗

Conditional Inactivation of the <i>Men1</i> Gene Leads to Pancreatic and Pituitary Tumorigenesis but Does Not Affect Normal Development of These TissuesSemantic proximity Read ↗

Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.Semantic proximity Read ↗

The Tumor Suppressor Protein Menin Inhibits AKT Activation by Regulating Its Cellular LocalizationSemantic proximity Read ↗

The multiple endocrine neoplasia type 1 gene product, menin, inhibits the human prolactin promoter activitySemantic proximity Read ↗

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Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis.Semantic proximity Read ↗

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