Article
Reproductive epigenetics.
Clinical genetics - 1 Apr 2004
Kelly T L J, Trasler J M
Abstract excerpt
Epigenetics refers to covalent modifications of DNA and core histones that regulate gene activity without altering DNA sequence. To date, the best-characterized DNA modification associated with the modulation of gene activity is methylation of cytosine residues within CpG dinucleotides. Human disorders associated with epigenetic abnormalities include rare imprinting diseases, molar pregnancies, and childhood...
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