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Article

Epigenetics: Definition, Mechanisms and Clinical Perspective

26 Aug 2009

Abstract excerpt

A vast array of successive epigenetic modifications ensures the creation of a healthy individual. Crucial epigenetic reprogramming events occur during germ cell development and early embryogenesis in mammals. As highlighted by the large offspring syndrome with in vitro conceived ovine and bovine animals, any disturbance during germ cell development or early embryogenesis has the potential to alter epigenetic...

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PMID: 19711245
DOI: 10.1055/s-0029-1237423

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