Article
[Detection of YMDD mutations in hepatitis B virus DNA with the use of allele specific polymerase chain reaction].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 2004
Pichkovskaia V A, Fevraleva I S, Ibragimova M M, Solov'eva T I, Drel' P E, Sudarikov A B
Abstract excerpt
Antiviral drug lamivudine has been widely used in the treatment of hepatitis B. However, it was demonstrated recently, that therapy by the drug is related with the selection of viral strains carrying mutations in C-domain of DNA polymerase/reverse transcriptase (YMDD-mutation). The mutation is the cause of resistance to lamivudine. An increase of the mutant population in the course of a long-term lamivudine...
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