Article
Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactions.
European journal of clinical pharmacology - 1 May 2004
Lee Ai-Young, Kim Min-Jung, Chey Won-Young, Choi Jun, Kim Byung-Gun
Abstract excerpt
BACKGROUND: Apart from allergic mechanisms, a lack or mutation of metabolic enzymes may cause adverse drug reactions. Patch testing has rarely been useful in cutaneous adverse drug reactions (CADRs) induced by diphenylhydantoin (DPH). Genetic polymorphisms leading to altered metabolic processes o...
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