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Article

Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Jun 2004

Schrauwen P, Hardie D G, Roorda B, Clapham J C, Abuin A, Thomason-Hughes M, Green K, Frederik P M, Hesselink M K C

Abstract excerpt

OBJECTIVE: An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity. METHODS: Mitocho...

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Source

Identifiers

PMID: 15024403
DOI: 10.1038/sj.ijo.0802629

Genes

UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15024403-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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