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Article

Histone H1 and the origin of protamines.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2004

Lewis John D, Saperas Núria, Song Yue, Zamora Maria Jose, Chiva Manel, Ausió Juan

Abstract excerpt

We present evidence that chordate protamines have evolved from histone H1. During the final stages of spermatogenesis, the compaction of DNA in many organisms is accomplished by the replacement of histones with a class of arginine-rich proteins called protamines. In other organisms, however, condensation of sperm DNA can occur with comparable efficiency in the presence of somatic-type histones or, alternatively,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15024099
DOI: 10.1073/pnas.0308721101
PMCID: PMC384709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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