Article
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen.
Spine - 1 Dec 2001
Sahlman J, Inkinen R, Hirvonen T, Lammi M J, Lammi P E, Nieminen J, Lapveteläinen T, Prockop D J, Arita M, Li S W, Hyttinen M M, Helminen H J, Puustjärvi K
Abstract excerpt
STUDY DESIGN: Skeletal tissues of mice with an inactivated allele of the Col2a1 gene for Type II collagen ("heterozygous knockout") were studied. OBJECTIVE: To determine whether a heterozygous inactivation of the Col2a1 gene has a role in the etiology of spine disorders such as disc degeneration. SUMMARY OF BACKGROUND DATA: Mutations in the COL2A1, COL11A1, COL11A2, and COL9A2 genes have been linked to spine...
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