Article
Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) - 15 Apr 2004
Verhofstede Chris, Noë Ann, Demecheleer Els, De Cabooter Nancy, Van Wanzeele Filip, Van Der Gucht Bea, Vogelaers Dirk, Plum Jean
Abstract excerpt
The aim of this study was to determine whether drug-resistant virus persists in peripheral blood mononuclear cells (PBMCs) after long-term suppression of virus replication. Proviral DNA was extracted from the PBMCs of 11 patients on long-term highly active antiretroviral therapy (HAART). Genotyping of the reverse transcriptase (RT) and protease gene of several proviral variants was performed using limiting...
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