Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy.

doi:10.1097/00126334-200404150-00005

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Article

Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy.

Journal of acquired immune deficiency syndromes (1999) - 15 Apr 2004

Verhofstede Chris, Noë Ann, Demecheleer Els, De Cabooter Nancy, Van Wanzeele Filip, Van Der Gucht Bea, Vogelaers Dirk, Plum Jean

Abstract excerpt

The aim of this study was to determine whether drug-resistant virus persists in peripheral blood mononuclear cells (PBMCs) after long-term suppression of virus replication. Proviral DNA was extracted from the PBMCs of 11 patients on long-term highly active antiretroviral therapy (HAART). Genotyping of the reverse transcriptase (RT) and protease gene of several proviral variants was performed using limiting...

Topics

Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Cohort Studies
Drug Resistance, Viral
Genetic Variation
Genotype
HIV Infections
HIV Protease
HIV Reverse Transcriptase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Humans

Leukocytes, Mononuclear

Molecular Sequence Data

Proviruses

Sequence Analysis, Protein

Time Factors

Source

Open in PubMed

Identifiers

PMID: 15021312
DOI: 10.1097/00126334-200404150-00005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15021312-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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