Article
Combined association between IFN-gamma 3,3 homozygosity and DRB1*03 in Löfgren's syndrome patients.
Immunology letters - 15 Feb 2004
Wysoczanska Barbara, Bogunia-Kubik Katarzyna, Suchnicki Krzysztof, Mlynarczewska Anna, Lange Andrzej
Abstract excerpt
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively were detected in sarcoidosis patients. IFN-gamma 3,3 homozygosity was found to constitute a risk...
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